PFT: Broncos use tag on Clady? |? Bears tag Melton

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When a quarterback or other offensive player has a big season out of the blue (typically as a rookie), defenses spend the next offseason obsessed with coming up with ways to stop him.? (Or, in the case of the 1999 Packers, devoting the first three rounds of the draft to finding guys who can cover Randy Moss.)

This year, it?s not just a player that will be forcing defensive coaches to burn the midnight oil in order to avoid getting toasted in 2013.? The read option has become the scheme that defenses will be committed to stopping next season.

It?s a simple concept.? The quarterback begins the process of handing the ball to a running back.? The quarterback reads the defensive end?s movement.? If the defensive end reacts as if the ball will be given to the running back, the quarterback takes it back and runs through the spot where the defensive end was.? If the defensive end stays homes or comes at the quarterback, the running back gets the ball.

Peter King of Sports Illustrated recently explained the manner in which defenses will react over the course of an offseason, pointing out that teams will be looking for cornerbacks who can cover without safety help, so that safeties will be able to support the effort to stop the read option.? Likewise, defensive ends will be asked to take a little steam out of their effort to crush the quarterback and to spend more time studying his movements.? Also, linebackers will be expected to balance preparing for the quarterback to let go of the ball that has been stuffed into the tailback?s gut and reacting to the possibility that the quarterback will yank the ball out and throw it to a receiver.

The Colts, whose desire to keep quarterback Andrew Luck healthy means they won?t be running the read option, nevertheless believe they can stop it.? Coach Chuck Pagano told Greg Cosell of NFL Films at the annual Maxwell Club awards dinner that defensive coaches don?t believe the read option will be a problem, once they have a chance to study it.

And here?s where offensive coordinators have an opportunity to think multiple moves ahead in the game of coaching chess.? As defenses reconfigure to stop the read option, other openings necessarily will arise.

As Cosell accurately observes, it?s still too early to know how the read option will develop and evolve, and whether it?s a fad like the CB radio or a new frontier like the Internet.

Source: http://profootballtalk.nbcsports.com/2013/03/01/ryan-clady-receives-franchise-tag/related/

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Andrew Mason Tweeting About Oranges Before ... - Business Insider

A day before he was fired, Groupon CEO Andrew Masonsent this cryptic tweet about attending a meeting of four people being asked to share three oranges in a meeting:

On Feb. 28, to announce he was let go, he tweeted:

The Jottit note linked to his quirky resignation letter, the one that said, "I've decided that I'd like to spend more time with my family. Just kidding - I was fired today."

In hindsight, the "oranges meeting" sounds ominous. So the question is, what was the deal with the three oranges? And who could have been the four people asked to share them?

Here's a thought: Mason was replaced by chairman Eric Lefkofsky and director Ted Leonsis. So those three people would have been in Mason's final meeting at Groupon, presumably. Mason and Lefkofsky hold controlling interests in Groupon stock along with one other board director: Brad Keywell.

Mason + Lefkofsky + Leonsis + Keywell = four people.

We tweeted at Mason for a comment. We'll let you know if he replies.

In the meantime, TheStreet?s Chris Ciacciaone noted this:

Source: http://www.businessinsider.com/andrew-mason-tweeting-about-oranges-before-he-was-fired-2013-3

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Sudan violating sanctions with Darfur air strikes: U.N. panel

UNITED NATIONS (Reuters) - Sudan's government has violated U.N. sanctions on the Darfur region by carrying out air strikes and using aircraft from Belarus and Russia despite pledging not to in the vast arid area in the country's west, U.N. experts say.

The U.N. Security Council's independent panel of experts - who monitor sanctions imposed on Darfur in 2005 - also said it was investigating whether Sudanese troops had violated the sanctions by using Iranian armored personnel carriers in Darfur.

Mainly African tribes in Darfur took up arms against the Khartoum government in 2003, complaining of political and economic marginalization. African Union peacekeepers were deployed in 2006 and replaced in 2008 by a joint AU-U.N. force.

In a report to the Security Council's committee on Sudan, made public on Friday, the panel said Sudan violated a Security Council resolution and written pledges to Belarus and Russia to not use aircraft purchased from them in Darfur by carrying out "aerial bombardments and intimidating flights."

"The panel received reliable information that the Sudanese armed forces had conducted several offensive military overflights and bombardments in Darfur using Antonov aircraft, Mi-24 attack helicopters, MiG-29 aircraft and Su-25 aircraft," said the report, which covers most of 2012.

The panel said the Sudanese government told them that the aircraft "had only limited-scale use and were in conformity with the rights of a sovereign state" and that "it emphasized that it would never use, nor had it previously used, its Darfur-based aviation assets to target its own people."

The arms embargo does not ban supplying military hardware, but countries must have a Sudan government guarantee that equipment and arms will not end up in Darfur.

NEW ROCKETS

The Security Council warned earlier this month that foreign military support such as spare parts, weapons systems and other materiel may be used in Darfur to support the aircraft deployed there in violation of Darfur sanctions.

The panel of experts report said that Sudan had started using a new weapons system - S-8 air-to-ground rockets - that Khartoum had purchased from Belarus in 2011 and promised not to use in Darfur in violation of the arms embargo.

"The panel observed many locations in the general area east of the Jebel Marra massif where remnants of these weapons are present," the report said.

During a visit to Darfur in December 2012, the panel also said it saw an unfamiliar type of armored personnel carrier at a Sudanese armed forces position. It said research showed the vehicle appeared to be a Rakhsh, manufactured in Iran by the Shahid Kolah Dooz Industrial Complex.

"The presence of this vehicle in Darfur is quite possibly an embargo violation. The panel is making further inquiries," the report said.

The panel saw Su-25 fighter jets - delivered to Sudan from Belarus between 2008 and 2010 - in Darfur, along with Mi-24 military attack helicopters bought from Russia in 2011. Russia and Belarus had both been given written pledges by Sudan that the aircraft would not be used in Darfur, the panel said.

Among several recommendations made by the panel, one was that states exporting military aircraft to Sudan "incorporate an electronic-tracking system ... to ensure that they are not used in violation" of Darfur sanctions and that the exporting states report any violations.

(Editing by Philip Barbara)

Source: http://news.yahoo.com/sudan-violating-sanctions-darfur-air-strikes-u-n-200749130.html

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The Weirdest Thing on the Internet Tonight: Synesthetic Locked

Not everybody needs LSD to see sound and hear smells, people with a neurological condition known as Synesthesia experience a sort of "cross-talk" between their senses. Director Oscar Lopez Rocha is one such synesthete. He shares what he sees in Synesthetic Locked. More »

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/2TCgyM5oWO4/the-weirdest-thing-on-the-internet-tonight-synesthetic-locked

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A nanogel-based treatment for lupus

Public release date: 1-Mar-2013
[ | E-mail | Share ]

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation

Systemic lupus erythematosus (SLE) is disease in which the immune system mistakenly attacks healthy tissues, resulting in inflammation and tissue damage. Current treatments are focused on suppression of the immune system, but these therapies can leave patients vulnerable to infection. In this issue of the Journal of Clinical Investigation, Tarek Fahmy and colleagues at Yale University report the development of a nanogel-based delivery system that targets an immunosuppressive drug (mycophenolic acid) directly to tissues associated with immune cells. A nanogel is composed of a polymer containing pores that can be loaded with drug compounds. Fahmy and colleagues tested the mycophenolic acid-loaded nanogel in a mouse model of lupus. Mice treated with the nanogel lived longer than untreated mice or mice treated with mycophenolic acid alone. Additionally, the onset of kidney damage, a common complication of lupus, was delayed in nanogel-treated mice. These studies suggest that nanogel-based therapies may be useful in the treatment of SLE.

###

TITLE:

Nanogel-based delivery of mycophenolic acid ameliorates systemic lupus erythematosus

AUTHOR CONTACT:

Tarek Fahmy
Yale University, New Haven, CT, USA
Phone: 203-512-1699; Fax: 203-432-1043; E-mail: tarek.fahmy@yale.edu

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 1-Mar-2013
[ | E-mail | Share ]

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation

Systemic lupus erythematosus (SLE) is disease in which the immune system mistakenly attacks healthy tissues, resulting in inflammation and tissue damage. Current treatments are focused on suppression of the immune system, but these therapies can leave patients vulnerable to infection. In this issue of the Journal of Clinical Investigation, Tarek Fahmy and colleagues at Yale University report the development of a nanogel-based delivery system that targets an immunosuppressive drug (mycophenolic acid) directly to tissues associated with immune cells. A nanogel is composed of a polymer containing pores that can be loaded with drug compounds. Fahmy and colleagues tested the mycophenolic acid-loaded nanogel in a mouse model of lupus. Mice treated with the nanogel lived longer than untreated mice or mice treated with mycophenolic acid alone. Additionally, the onset of kidney damage, a common complication of lupus, was delayed in nanogel-treated mice. These studies suggest that nanogel-based therapies may be useful in the treatment of SLE.

###

TITLE:

Nanogel-based delivery of mycophenolic acid ameliorates systemic lupus erythematosus

AUTHOR CONTACT:

Tarek Fahmy
Yale University, New Haven, CT, USA
Phone: 203-512-1699; Fax: 203-432-1043; E-mail: tarek.fahmy@yale.edu

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-03/joci-ant022213.php

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Seamlessly Sync Photos Between Android and PC

The Last Mile has been the challenge of industries immemorial. What, you say? Well, humor me, and I'll tell you. "Last Mile" -- usually -- refers to the last part of a network, the bit that delivers communications directly into a home. It's often the hardest and most expensive part.

Source: http://ectnews.com.feedsportal.com/c/34520/f/632000/s/290e8b06/l/0L0Stechnewsworld0N0Crsstory0C774120Bhtml/story01.htm

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home improvement ? the longest day ? 522 part 3.wmv | Home ...

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Source: http://sangbayang.info/1114-home-improvement-the-longest-day-522-part-3-wmv

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